Open-Source Liquid Handler

Open-Source Liquid Handler

OTTO is a liquid handler that can automatically prepare samples for qPCR, flow cytometry, and other biological assays that rely on accurate liquid dispensing. Otto is also:

  • a linear motion platform that balances speed and accuracy for timely sample preparation
  • capable of lights out sample preparation (set it up and walk away!)
  • constructed entirely from open-source parts
  • affordable, costing ~$1500

Learn how to build OTTO’s mechanical, Electrical, and Software components.

Watch OTTO in action.

Autodesk Fusion 360 Model

(It may take a couple seconds to load )

About the Inventors

OTTO was the brainchild of David Florian, who is a graduate student in Dr. Scott Guelcher’s lab at Vanderbilt. With the help of his advisor and a passionate group of undergraduates (Mateusz Odziomek, Cerie Ock, and Hannah Chen), David brought OTTO to life.

Interested in lab automation or biomaterials? Learn more about the Guelcher lab here.


OTTO is distributed under the MIT License. Therefore, it is completely open-source. Build and improve it!